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Most movies don't know how to handle cancer. Heck, most people don't know how to handle cancer — and I'm not talking about the patients. Cancer, or any other terminal illness for that matter, almost always plays some kind x-factor in a film — that is when a film even dares to enter a realm often deemed depressing and 'not for the movies.' Most often, scripts will position cancer as a tearjerking emotional turning point in a film or as the initial spark of some banal 'live life to the fullest' comedy.

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Watch 50/50 starring Joseph Gordon-Levitt in this Independent on DIRECTV. It's available to watch on TV, online, tablets, phone. Adam Lerner (Joseph Gordon-Levitt) has always tried to take good care of his health, so it comes as a cruel surprise when he learns that he has malignant tumors along his spine.

'50/50' puts an end to that. Written semi-autobiographically by cancer survivor Will Reiser, it would seem it takes one to write one.

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Although cancer drives the entire story, the story doesn't fixate on cancer or melodramatize the terrible truths we already know about potentially fatal illness. Perhaps you could tell as much from the trailer thanks to some typical Seth Rogen antics, but the injection of contemporary R-rated humor is neither irreverent, insensitive nor an attempt to simply put a positive spin on a depressing subject. Life — believe it or not — doesn't stop for cancer.